Since 1833 the Presbyterian Church (U.S.A.) has been in mission service around the world.The Worldwide Ministries Division (WMD) empowers the church in each place to share the transforming power of the gospel of Jesus Christ with all people. The staff of about 100 members is divided into three main work areas. One sends people, one sends resources, and one builds relationships with partner churches.

Global Service and Witness mobilizes the faithful and advocates for the General Assembly in public policy debates. It has seven grant-making and scholarship programs:

Presbyterian Disaster Assistance
Presbyterian Hunger Program
Self-Development of People
Global Education and International Leadership Development
International Evangelism
International Health Ministries
Jinishian Memorial Program

People in Mutual Mission recruits , sends, and sustains mission personnel. They facilitate and enhance the work of approximately 400 long-term and 75 short-term missionaries. Long-term mission personnel have Web pages and are available as mission speakers . Staff facilitates mission teams and study seminars .

Ecumenical Partnerships develops and nurtures partnership relationships of the PC(USA) with 165 or so churches and institutions in over 80 countries around the world. The staff also works with congregations, presbyteries and synods to develop international mission partnerships with corresponding entities. Relations with interfaith and ecumenical bodies are also sustained by these offices.